One of the most important rules of devotion is to consider oneself to be more insignificant than a blade of grass.   When we consider ourselves to be important, we forget the significance of God.  But when we remember how significant God is, then we realize our own insignificance.  We are just one soul out of billions of souls on planet earth. The earth is just one planet out of billions of stars in the Milky Way galaxy and the Milky Way galaxy is just one out of billions of other galaxies in our universe.

According to the Vedas, like our universe there are innumerable universes of differing sizes and features.  Every time, Maha Vishnu breathes in, unlimited universes manifest from the pores of his body, and when he breathes out, all the universes dissolve back.  Each universe has one Brahma, one Vishnu and one Shankar. So there are innumerable Brahamas, Vishnus and Shankars in innumerable universes.   Still the magnitude of God’s glory cannot be judged because the material universes only comprise a fraction of his being. The material creation consisting of unlimited universes is only one-fourth of God’s entire manifestation; the remaining three-fourth is the spiritual creation.  What is our significance compared with the Lord of the unlimited universes?

The significance is only of our ego.  Egotism is the conscious awareness of “I”, “me”, and “mine”.  Because of the ego the soul identifies with the bodily identifications and becomes proud of things like wealth, status, beauty, and learning.  It creates the biggest untruth in our lives, and makes us believe what we are not.  It is ego that blocks the glory of God from shining through us as it makes us forget the significance of God. 

Saint Kabir puts it very beautifully in his doha:

Here ‘main’ refers to the ego. Therefore all the Saints have emphatically declared that if we wish to invite God into our hearts, we must get rid of the pride of the self.  To give up the ego we must remember God as the source of all our actions and our abilities.  If God did not supply our body-mind-mechanism with the power to perform actions, we could have done nothing.  Hence every time debilitating thoughts of ego swell in our hearts we should remind ourselves of the significance of God – He is the source and we are only his instruments.